Transition metal-catalyzed carbonylative cross-coupling reactions

    Transition metal-catalyzed carbonylative cross-coupling reactions are some of the most widely used methods in organic synthesis. However, despite the obvious advantages of iron 
as an abundant and low toxicity transition metal catalyst, its practical application in carbonylation reaction remains largely unexplored. 
    Recently, Prof. Wu et.al.report Fe-catalyzed alkoxycarbonylation of alkyl halides at Angew. Chem. Int. Ed. 2022. (https://doi.org/10.1002/anie.202211939). Both o-phenanthroline derivatives, 5-nitro-1,10-phenanthroline CAS:4199-88-6 and 1,10-phenanthroline-5,6-dione CAS:27318-90-7 were employed as ligand and extended its substrate scope. Mechanistic studies indicate that the reaction is catalyzed by an in-situ generated Fe²⁻complex. This low-valent iron species activates alkyl bromides via a distinctive two electron transfer (TET) process, whereas it proceeds via a single electron transfer (SET) process for alkyl iodides which is consistent with literature.
    The both ligands, o-phenanthroline derivatives, 5-nitro-1,10-phenanthroline CAS:4199-88-6 and 1,10-phenanthroline-5,6-dione CAS:27318-90-7 has been supplying in kilograms from UCHEM.